Week 6 of the 2025 NFL season comes to a close on Monday night with not one but two different matchups, and the first of the bunch is a cross-conference test: The Buffalo Bills are widely regarded as one of the league's top Super Bowl contenders, leading the AFC East at 4-1, while the Atlanta Falcons are trying to stay in the mix of a crowded NFC South after an uneven 2-2 start.Buffalo is coming off its first loss of the year, a 23-20 stunner at the hands of the rival New England Patriots, but logged four straight wins to open the season, three of which were multi-score routs. Atlanta, meanwhile, got a confidence-boosting shootout win over the Washington Commanders prior to resting up on its Week 5 bye. Now the Falcons are motivated to show they're capable of keeping pace with NFL heavyweights. The national stage simply underscores the challenge at hand.Is Michael Penix Jr. primed for a prime-time breakout while dueling with Josh Allen and the Bills? Or is Allen simply too good to contain, with 12 total touchdowns through Buffalo's first five games as a candidate to repeat as NFL MVP? Either way, this is a must-see matchup -- a chance for the Bills to get right under the Monday night lights, and a chance for the Falcons to prove they're not just scrappy but legitimate challengers for their first division crown in close to a decade.Stay tuned here for live updates and analysis.Where to watch Bills vs. Falcons liveWhen: Monday, Oct. 13 | Time: 7:15 p.m. ETWhere: Mercedes-Benz Stadium (Atlanta)TV: ESPN | Stream: fubo (try for free)Follow: CBS Sports AppOdds: Bills -3.5, O/U 50 (via DraftKings Sportsbook)
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